Pyridines and derivatives

Aromatic organic compounds consist of an aromatic six-membered ring containing one nitrogen atom and five carbon atoms; includes compounds derived from pyridines.

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5,491 – 5,505 of 178,220 results

5,491

Medchemexpress LLC Benzeneacetamide, N-[4-[2,3-dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]- | 3025286-00-1 | 99.1% | 826.92 | 25 MG

Nrf2 degrader 1 is a PROTAC Nrf2 degrader with a DC50 of 0.1-1 μM in huH1 cells. It inhibits cancer cell growth for A549 and LK-2 cells with IC50 values of 100 nM and 40 nM, respectively. This compound is used for the study of liver cancer, non-small cell lung cancer (NSCLC), and squamous cell carcinoma of lung cancer. The chemical structure involves an Nrf2 Target protein ligand, a Cereblon ligand, and a linker.

Inhibits cancer cell viability with IC50 values of 100 nM for A549 cells and 40 nM for LK-2 cells
Composed of an Nrf2 target protein ligand, a Cereblon ligand (HY-41547), and a linker
Used in the study of liver cancer, non-small cell lung cancer, and squamous cell carcinoma of lung cancer
For research use only

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5,492

Medchemexpress LLC HJ445A | 3032441-59-8 | 98.3% | 445.52 | 5 MG

HJ445A is a potent MYOF inhibitor that binds to the MYOF-C2D domain with a KD of 0.17 μM. It repressed the proliferation of gastric cancer cells with IC50 values of 0.16 and 0.14 μM in MGC803 and MKN45, respectively. HJ445A shows superior antitumor efficacy in vivo and is suitable for cancer research.

Potent MYOF inhibitor
Represses proliferation of gastric cancer cells
Demonstrates superior antitumor efficacy in vivo
Can be used for cancer research

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5,493

Medchemexpress LLC MEDCHEMEXPRESS LLC

5000697456 RMC-113 50MG

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5,494

Medchemexpress LLC N-[4-(3-bromoanilino)quinazolin-6-yl]prop-2-enamide | 194423-15-9 | 98.6% | C17H13BrN4O | 10MG

PD168393 is a potent, selective, cell-permeable irreversible inhibitor of EGFR and ErbB2 tyrosine kinases. It covalently modifies the receptor active site and is used in biochemical and cellular studies to probe EGFR/ErbB2 signaling and inhibition.

High potency and selectivity for EGFR and ErbB2.
Irreversible covalent inhibitor mechanism for sustained target engagement.
Cell-permeable, suitable for cellular assays.
High purity (>98% by HPLC) appropriate for research use.
Molecular formula C17H13BrN4O; molecular weight 369.22 g·mol⁻¹.

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5,495

Medchemexpress LLC FITC-Dextran MW 400 | 60842-46-8 | 40,000 (average) | 5 MG

FITC-dextran (average molecular weight 40,000) is a fluorescein isothiocyanate-labeled dextran polymer used as a fluorescent tracer for permeability and cell-damage studies. It produces bright green fluorescence (Ex 495 nm/488 nm; Em 525 nm) and is commonly applied to assess barrier integrity, visualize paracellular permeability, and detect heat shock-induced cell damage or apoptosis in microscopy and permeability assays.

Bright green fluorescence suitable for microscopy and flow cytometry (Ex 495/488 nm; Em 525 nm).
Average molecular weight ≈ 40,000 for tracer and permeability experiments.
Useful for barrier integrity assays, including blood-brain barrier and epithelial permeability.
Polydisperse polymer provides size-dependent permeability information.
Supplied in small laboratory quantities for convenient assay setup.

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5,496

Cayman Chemical SC514 Inhibitors

A selective and reversible inhibitor of IKK2 (IC50 = 3-12 μM) that displays >10-fold selectivity over 28 other kinases; attenuates NF-κB-mediated gene expression in synovial fibroblasts, smooth muscle cells, and astrocytes

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5,497

Cayman Chemical F16 Fluorescent

A potential antitumor agent; binds preferentially to mitochondrial membranes and disrupts their function; induces apoptosis in HER-1/EGFR-expressing breast carcinoma cell lines; can be used to visualize mitochondria under confocal microscopy

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5,498

Cayman Chemical 1 2Dihexanoylsnglycerol

An analog of the PKC-activating second messenger DAG

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5,499

Cayman Chemical 13 14dihydro15keto Prostaglan

An internal standard for the quantification of 13,14-dihydro-15-keto PGE2 by GC- or LC-MS

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5,500

Cayman Chemical Lavendustin C Inhibitors

A potent tyrosine kinase inhibitor; inhibits EGF receptor-associated tyrosine kinase, pp60c-src(+) kinase, and Ca2+ calmodulin-dependent kinase II (IC50s = 0.012, 0.5, and 0.2 µM, respectively); inhibits tyrosine kinase-associated neutrophil degranulation and superoxide generation at 10-150 µM

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5,501

Cayman Chemical Fluvastatin Inhibitors

An HMG-CoA reductase inhibitor (Ki = 0.3 nM for the rat enzyme); inhibits CYP2C9 (IC50 = 100 nM); inhibits oxidized LDL-induced ferroptosis and reverses oxidized LDL-induced decreases in GPX4 and system Xc- levels in HUVECs; decreases serum cholesterol, triglyceride, and phospholipid levels, the formation of TBARS, and vascular ACE activity in rabbits fed a high-cholesterol diet at 2 mg/kg per day; increases survival in a mouse model of myocardial infarction at 10 mg/kg per day

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5,502

Cayman Chemical CAY10567 Inhibitors

An inhibitor of Akt1 translocation that also inhibits hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase (RdRp) (IC50 = 79 µM)

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5,503

Medchemexpress LLC (S)-1-(3-(benzyloxy)isoxazol-5-yl)-N,N-dimethylprop-2-en-1-amine | 951698-15-0 | 99.1% | C15H18N2O2 | 10MG

TP748 is an isoxazole building block used as a key intermediate in the chemical synthesis of fully synthetic tetracycline derivatives. Supplied for research use, it is provided as a high-purity solid suitable for synthetic and medicinal chemistry workflows.

High purity (99.1%).
White to off-white solid.
Molecular formula C15H18N2O2; molar mass 258.32 g/mol.
Soluble in DMSO (100 mg/mL).
Powder stable at -20°C for long-term storage.
Designed for use as a synthetic intermediate in tetracycline chemistry.

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5,504

Cayman Chemical G1 Other Receptor Modulators

G-1 is a nonsteroidal, high-affinity, selective agonist of GPR30 that binds with a Ki value of 11 nM. Competitive binding studies in estrogen receptor α- (ERα-) and ERβ-expressing cells yielded Ki values for estradiol of 0.30 and 0.38 nM, respectively, with no substantial binding of G-1 at 1 µM.{14210} The discovery of G-1, a compound that does not bind classical ERs, should facilitate further physiological experiments to define the role of GPR30 in vivo.

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5,505

Cayman Chemical AS605240 Inhibitors

A potent inhibitor of PI3Kγ; inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner (IC50s = 8, 60, 270, and 300 nM, respectively); inhibits C5a-mediated phosphorylation of protein kinase B in RAW 264 cells (IC50 = 90 nM); suppresses joint inflammation in mouse models of rheumatoid arthritis; reduces RANTES-induced peritoneal neutrophil recruitment in a mouse model of leukocyte chemotaxis (ED50 = 9.1 mg/kg)

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Pyridines and derivatives

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Medchemexpress LLC HJ445A | 3032441-59-8 | 98.3% | 445.52 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC MEDCHEMEXPRESS LLC Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC N-[4-(3-bromoanilino)quinazolin-6-yl]prop-2-enamide | 194423-15-9 | 98.6% | C17H13BrN4O | 10MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC FITC-Dextran MW 400 | 60842-46-8 | 40,000 (average) | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Cayman Chemical SC514 Inhibitors Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Cayman Chemical F16 Fluorescent Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Cayman Chemical 1 2Dihexanoylsnglycerol Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Cayman Chemical 13 14dihydro15keto Prostaglan Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Cayman Chemical Lavendustin C Inhibitors Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Cayman Chemical Fluvastatin Inhibitors Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Cayman Chemical CAY10567 Inhibitors Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (S)-1-(3-(benzyloxy)isoxazol-5-yl)-N,N-dimethylprop-2-en-1-amine | 951698-15-0 | 99.1% | C15H18N2O2 | 10MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Cayman Chemical G1 Other Receptor Modulators Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Cayman Chemical AS605240 Inhibitors Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More